Expression of secretoglobin family 2A member 2 in oral lichen planus lesions.
- Author:
Xiao-an TAO
1
;
Jian-yong XIAO
;
Qi ZENG
;
Bin CHENG
2
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Blotting, Western; Female; Gene Expression Regulation; Humans; Immunohistochemistry; Lichen Planus, Oral; genetics; metabolism; Male; Mammaglobin A; genetics; metabolism; Middle Aged; Mouth Mucosa; metabolism; RNA, Messenger; metabolism; Reverse Transcriptase Polymerase Chain Reaction; Young Adult
- From: Chinese Journal of Stomatology 2013;48(10):606-609
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the expression of secretoglobin family 2A member 2 (SCGB2A2) (mammaglobin A, MGB1) in oral lichen planus (OLP) lesions.
METHODSSixteen OLP patients and 10 healthy controls were included in this study. The real time reverse transcription-PCR (RT-PCR), Western blotting and immunohistochemistry (IHC) were used to determine the mRNA and protein of SCGB2A2.
RESULTSCompared with healthy controls (0.48 ± 0.09), the expression of SCGB2A2 protein in OLP lesions significantly increased (1.02 ± 0.11) (P < 0.05).However, the mRNA level of SCGB2A2 in lesions was significantly lower than that in controls (P < 0.05).
CONCLUSIONSThese results suggest that SCGB2A2 may be involved in pathogenesis of OLP.
