Association of CD4+ T lymphocyte count and gingival crevicular fluid prostaglandin E2 with periodontal parameters in HIV-positive periodontitis patients
10.3760/cma.j.issn.1002-0098.2014.02.003
- VernacularTitle:HIV阳性的牙周炎患者CD4+ T淋巴细胞计数和龈沟液前列腺素E2与牙周临床指标的相关性分析
- Author:
Hongcheng JIA
1
;
Xuan WANG
;
Wenhao HUA
;
Xiaoguang LI
;
Wen HOU
;
Qian FU
Author Information
1. 100015,首都医科大学附属北京地坛医院口腔科
- Keywords:
Prostaglandins E;
Human immunodeficiency virus proteins;
Periodontitis;
CD4 lymphocyte count
- From:
Chinese Journal of Stomatology
2014;49(2):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of CD4+ T lymphocyte count and prostaglandin E2 (PGE2) in gingival crevicular fluid(GCF) with periodontal status in HIV-positive patients with periodontitis.Methods Twenty subjects were selected according to inclusion criteria.The plasmatic CD4+ T lymphocytes were counted.All the individuals were divided into three groups,group A (CD4+ T lymphocyte count ＜200 cell/mm3),group B (200 cell/mm3 ≤CD4+ T lymphocyte count≤500 cell/mm3) and group C (CD4+ T lymphocyte count ＞ 500 cell/mm3).Periodontal indexes,including plaque index (PLI),bleeding index(BI),attachment level(AL) and probing depth(PD) were recorded.GCF samples were taken from 120 index teeth by means of sterile paper strips.GCF PGE2 levels were determined by radioimmunoassays.MannWhitney was used to compare the periodontal indexes and PGE2 levels among the three groups.Partial correlations and Spearman correlations were applied to analyze the correlation of CD4+ T lymphocytes count and PGE2 in gingival crevicular fluid with periodontal status.Results BI value,PGE2 concentration and total PGE2 were 3.00 (2.00),90.75 (30.60) μg,/L,447.58 (243.08) pg in group B,which were higher than those in group A[2.00(1.25),79.75(30.50) μg/L and 339.52(200.97) pg respectively] and group C [2.00(1.00),73.38 (14.83) μg/L and 299.18 (108.33) pg respectively] (P ＜ 0.0167).But the differences of PD and AL among the three groups were not significantly different (P ＞ 0.0167).The correlations were observed between CD4+ T lymphocyte count and BI for the subpopulations with CD4+ T lymphocyte count ＜ 200 cells/mm3 (r =0.657,P ＜ 0.05) and between 200-500 cells/mm3 (r =-0.369,P ＜ O.05).PGE2 concentration was negatively correlated with BI,PD and AL(P ＜ 0.05),and total PGE2 was positively correlated with PD and AL (P ＜ 0.05).Conclusions There was an association between the periodontal status and CD4+ T lymphocyte count in HIV + patients.GCF PGE2 level was related to periodontal parameters including BI,PD and AL.
