Preliminary application of injectable calcium phosphate cement/poly (lactic-co-glycolic acid) microspheres for extraction site preservation
10.3760/cma.j.issn.1002-0098.2014.03.012
- VernacularTitle:磷酸钙骨水泥与聚乳酸-羟基乙酸微球复合物用于拔牙位点骨质保存的动物实验
- Author:
Yuying MAI
1
;
Huihuang WU
;
Zhisong MAI
;
Xinghong LI
;
Linhui HUANG
;
Hongbing LIAO
Author Information
1. 广西医科大学口腔医学院口腔修复科
- Keywords:
Calcium phosphates;
Alveolar bone loss;
Animals,laboratory;
Poly (lactic-co-glycolic acid)
- From:
Chinese Journal of Stomatology
2014;49(3):180-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feasibility of extraction site preservation using injectable calcium phosphate cement (CPC) combine with poly (lactic-co-glycolic acid) (PLGA) microspheres.Methods Immediate extraction defects models were created in canine mandibles,and the defects were filled with CPC/PLGA (experimental group,E),Bio-Oss (positive control,P),non-treatment (blank control,B) respectively.Dogs were sacrificed after 4,8,12 weeks post operation.Statistical analysis were conducted using SPSS 19.Results Results of radiological observation showed that there were not significantly different between groups in 4 and 8 week(P ＞0.05).After 12 week,E(114.9 ±8.4)were not significantly different compared with P(117.4 ± 12.1) (P ＞ 0.05),both were significantly higher than B (95.0 ± 12.6)(P ＜0.05).Histology examination showed that at 4 week following surgery,the result of newly formed bone was as follow,P [(87.5 ± 1.5) ％] ＞ B [(78.7 ± 2.7) ％] ＞ E [(69.2 ± 1.8) ％] (P ＜ 0.05).At8,12 week,results of P[(94.0 ±2.3)％ and (93.5 ±1.9)％]and E[(94.7 ±1.1)％ and (96.0±0.9)％] were better than those of B[(76.8 ±3.0)％ and (87.0 ±2.4)％] (P＜0.05).Conclusions The effect of CPC/PLGA repair immediate alveolar ridge defects is the same as that of BioOss,and CPC/PLGA can be used as a material in extraction site preservation.
