Exosomes Derived from Mesenchymal Stem Cells--the Future Ideal Vector of Biological Therapy.
10.7534/j.issn.1009-2137.2015.04.053
- Author:
Juan ZHANG
1
;
Jing-Shu SHI
1
;
Jian LI
2
Author Information
1. Jiangxi Provincial Key Laboratory of Hemotologic Diseases, Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
2. Jiangxi Provincial Key Laboratory of Hemotologic Diseases, Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. E-mail: thj127900@163.com.
- Publication Type:Journal Article
- MeSH:
Biological Therapy;
Cell Communication;
Exosomes;
Humans;
Mesenchymal Stromal Cells;
MicroRNAs
- From:
Journal of Experimental Hematology
2015;23(4):1179-1183
- CountryChina
- Language:Chinese
-
Abstract:
MSC-exosomes are homogeneous menbrane vesicles with diameter 40-100 nm, derived from mesenchymal stem cells at physiological or pathology conditions. MSC-exosomes contain a great quantity and a wide variety of bioactive substances, such as proteins and miRNA. MSC-exosomes transfer bioactive substances to recipient cells to affect their functions through membrane fusion or endocytosis, which like the storage pools of signal vehicles for cell-to-cell comunication in vivo. MSC-exosomes can mimic the beneficial effect of MSC treatment, such as the promotion of tissue repair or the immune regulation. The biological property and functions of MSC-exosomes are reviwed in this article.
