Effect of Ikaros in B Cell Acute Lymphoblastic Leukemia.
10.7534/j.issn.1009-2137.2015.04.056
- Author:
Hai-Ying ZHANG
1
,
2
;
Hai BAI
1
;
Author Information
1. Department of Hematology, Center of Hematologic Diseases of Chinese PLA
2. Lanzhou Military Commond General Hospital, Lanzhou 730050, Gansu Province, China.
- Publication Type:Journal Article
- MeSH:
B-Lymphocytes;
Cell Differentiation;
Genes, Tumor Suppressor;
Humans;
Ikaros Transcription Factor;
Mutation;
Precursor Cell Lymphoblastic Leukemia-Lymphoma
- From:
Journal of Experimental Hematology
2015;23(4):1194-1198
- CountryChina
- Language:Chinese
-
Abstract:
The Ikaros - a DNA-binding zinc finger protein, acting as a regulator of chromatin remodeling and gene transcription, is crucial for regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Function-loss mutations of IKZF1, gene encoding Ikaros are frequent in B cell acute lymphoblastic leukemia (B-ALL) and are associated with a poor prognosis. This review briefly summarizes the available data regarding the structure and function of Ikaros, the role of Ikaros as a tumor suppressor in B-ALL, and its regulation mechanism.
