Relation of MBL ExonI 54 and NFκB1-94ins/del ATTG Polymorphism with Fever during Neutropenia in Patients with Acute Leukaemia after Chemotherapy.

Wen-ning XU; Zu-jun Jiang; Yong-hua LI; Hao-wen Xiao; Yang Gao; Yan Pang; Lin Ouyang; Zeng-hui Liu; Le-qing Zhang; Yang Wang; Yang Xiao

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Relation of MBL ExonI 54 and NFκB1-94ins/del ATTG Polymorphism with Fever during Neutropenia in Patients with Acute Leukaemia after Chemotherapy.

Author: Wen-Ning XU ¹ ; Zu-Jun JIANG ¹ ; Yong-Hua LI ¹ ; Hao-Wen XIAO ¹ ; Yang GAO ¹ ; Yan PANG ¹ ; Lin OUYANG ¹ ; Zeng-Hui LIU ¹ ; Le-Qing ZHANG ¹ ; Yang WANG ¹ ; Yang XIAO ²
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1. Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.
2. Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China. E-mail: jdxiao111@163.com.
Publication Type:Journal Article
MeSH: Acute Disease; Exons; Fever; Genotype; Humans; INDEL Mutation; Leukemia; drug therapy; genetics; Mannose-Binding Lectin; genetics; NF-kappa B p50 Subunit; genetics; Neutropenia; Polymorphism, Single Nucleotide
From: Journal of Experimental Hematology 2015;23(5):1258-1264
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the correlation between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism and fever during neutropenia in patients with acute leukaemia (AL) (except M3) after first chemotherapy in Chinese Han population.
METHODSBlood samples obtained from 76 fever patients with AL during neutropenia episodes were detected to analyse single nucleotide polymorphism (SNP) in the MBL ExonI 54 and NFκB1-94ins/del ATTG gene, and analyse the correlation between above-mentioned 2 polymorphisms and fever during neutropenia of AL patients after chemotherapy.
RESULTSIn 76 patients, no correlation were found between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism and fever during neutropenia in patients with acute leukaemia after chemotherapy (P > 0.05). No significant relation were found in sex, age, underlying disease, disease status or degrees of neutropenia in febrile neutropenia between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism (P > 0.05). However, patients with MBL ExonI 54 mutation presented longer febrile duration with a median of 5 days compared to 3 days of patients with wildtype MBL ExonI 54 genotype (P < 0.05).
CONCLUSIONSThere is no clear correlation between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism and fever during neutropenia in patients with acute leukaemia after chemotherapy. However, the patients with MBL ExonI 54 mutation have been observed to present a longer febrile duration.