A Survey for Colton and Other 3 Rare Blood Group Systems in Chinese Nanjing Han Population.
- Author:
Yan CHEN
1
;
Ling MA
1
;
Yan-Chun LIU
2
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Asian Continental Ancestry Group; genetics; Blood Donors; Blood Group Antigens; genetics; Blood Transfusion; China; Humans; Multiplex Polymerase Chain Reaction
- From: Journal of Experimental Hematology 2015;23(5):1474-1477
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution of Colton, Diego, Kell and Yt rare blood groups in Chinese Nanjing Han population, so as to improve the transfusion capability of patients with rare blood group and to further enrich the rare-blood-donor bank.
METHODSA total of 2 015 blood samples from the blood donors were selected randomly to screen the presence of K⁺ and Kp(c+) (Kell), Yt(b+) (Yt), Co(b+) (Colton), Di(a+b+) and Di(a+b-) (Digeo) antigen allele by using PCR and multiplex PCR.
RESULTSOut of 2005 samples, 1 case with K⁺ gene, 8 cases with Yt(b+) gene and 100 cases with Di(a+b+) gene, 2 cases with Di(a+b-) were identified, while no Kp(c+) and Co(b+) were detected.
CONCLUSIONThe frequencies of K⁺, Yt(b+) and Di(a+), Di(b+) are 0.0003, 0.0013 and 0.0258, 0.9742, respectively. They are very rare blood groups in Chinese Nanjing Han population.
