Epidemiologic Survey of Blood Donors with HBsAg⁻/HBV DNA⁺ in Chinese Xiamen Area.
- Author:
Shan-Hai OU
1
;
Jin-Zhen XIA
1
;
Yong-Cai LIN
1
;
Chang-Rong CHEN
2
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; Blood Donors; China; epidemiology; DNA, Viral; blood; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis B; epidemiology; Hepatitis B Surface Antigens; blood; Hepatitis B virus; Humans; Male; Nucleic Acid Amplification Techniques
- From: Journal of Experimental Hematology 2015;23(5):1483-1487
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo understand the characteristics of infections from blood donors with HBsAg⁻/HBV DNA⁺ in Xiamen area.
METHODSDonors in Xiamen area were assayed by routine ELISA and those with negative results were tested by nucleic acid amplification testing (NAT). HBsAg⁻/HBV DNA⁺ samples were tested by quantitative detection of HBV DNA. Epidemiological analysis and following up examination were conducted in HBsAg⁻/HBV DNA⁺ donors.
RESULTSOut of 130659 samples 113 were tested as HBsAg⁻/HBV DNA⁺ and with a rate of 0.09%. Among those, 62 samples were tested by quantitative detection of HBV DNA. All of the quantitative results were less than 1 × 10³ IU/ml and 93.5% (58/62) of which were less than 100 IU/ml. The possitive rate of HBsAg⁻/HBV DNA⁺ donors rose with ages. The possitive rate in male donors was higher than that in female and was lower in highly educated ones. Students and public servants had a lower positive rate.
CONCLUSIONThe possitive rate of HBsAg⁻/HBV DNA⁺ donors is higher in Xiamen and the distribution of possitive donors has certain epidemiological characteristics. It is necessary to mobilize and recruit more people with a lower rate of HBsAg⁻/HBV DNA⁺ infection.
