Chromosomal Aberrations in Myelodysplastic Syndromes.
10.7534/j.issn.1009-2137.2015.05.055
- Author:
Xiao RU
1
;
Ling-Yan ZHANG
2
;
Ying LI
1
Author Information
1. Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China.
2. Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China. E-mail: zlyzly2002@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Cell Transformation, Neoplastic;
Chromosome Aberrations;
Chromosome Disorders;
Humans;
Leukemia;
Myelodysplastic Syndromes;
genetics;
Prognosis
- From:
Journal of Experimental Hematology
2015;23(5):1509-1512
- CountryChina
- Language:Chinese
-
Abstract:
Myelodysplastic syndromes (MDS) are a group of clonal hematopioetic disorders characterized by myelodysplasia, decreased peripheral blood cells and high-risk of transformation into acute leukemia. MDS are often accompanied by a variety of chromosomal aberrations which play a role in disease pathogenesis, and are crucial in diagnosis and prognostic evaluation of this disease. About half of the patients with MDS have chromosomal abnormalities, mainly unbalanced chromosomal aberration. Different chromosomal aberration types are associated with different clinical outcome of this disease. Though balanced chromosomal translocations are not common in MDS, it seems that the patients with them have a higher leukemia transformation rate than those with other type of chromosomal aberrations. In this review, the chromosomal aberrations in MDS and their clinical significance for diagnosis and prognosis are briefly summarized.
