Research Progress on Expression and Function of P2 Purinergic Receptor in Blood Cells.
10.7534/j.issn.1009-2137.2015.05.057
- Author:
Wen-Li FENG
1
;
Li-Na WANG
1
;
Guo-Guang ZHENG
2
Author Information
1. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
2. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. E-mail: zhengggtjchn@aliyun.com.
- Publication Type:Journal Article
- MeSH:
Adenosine Triphosphate;
Blood Cells;
physiology;
Cell Differentiation;
Cell Movement;
Cell Proliferation;
Hematopoiesis;
Humans;
Receptors, Purinergic P2;
physiology;
Signal Transduction
- From:
Journal of Experimental Hematology
2015;23(5):1517-1522
- CountryChina
- Language:Chinese
-
Abstract:
Nucleotides have unambiguously emerged as a family of mediators of intercellular communication, which bind a class of plasma membrane receptors, P2 purinergic receptors, to trigger intercellular signaling. P2 receptors can be further divided into two structurally and functionally different sub-famlies, the P2X and P2Y receptors. Different blood cells express diverse spectrum of P2 receptors at different levels. Extracellular adenosine triphosphate (ATP) exerts different effects on blood cells, regulating cell proliferation, differentiation, migration, chemotaxis, release of cytokines or lysosomal constituents, and generation of reactive oxygen or nitrogen species. The relationship between abnormal P2 receptors and human diseases attracts more and more attention. This review briefly discusses the expression and function of P2 receptors in hematopoietic system.
