Research Progress on Muscle-derived Stem Cells Capable of Hematopoiesis.
10.7534/j.issn.1009-2137.2015.05.058
- Author:
Yu-Fang CHEN
1
;
Yuan-Yuan WANG
1
;
Juan-Juan WANG
2
;
Xiao-Ning GAO
2
;
Xiao-Ling WANG
2
;
Shu-Wu ZHAO
2
;
Tao WANG
3
;
Hao-Ying DOU
4
Author Information
1. Department of Nursing, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
2. College of Tradional Chinese Medicine Integrated with Western Medicine, Tianjin Uneversity of Traditional Chinese Medicine, Tianjin 300193, China.
3. College of Tradional Chinese Medicine Integrated with Western Medicine, Tianjin Uneversity of Traditional Chinese Medicine, Tianjin 300193, China. E-mail: wangtao6112@163.com.
4. Department of Nursing, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. E-mail: douhaoying11@126.com.
- Publication Type:Journal Article
- MeSH:
Anemia, Aplastic;
Cell Differentiation;
Cell Proliferation;
Hematopoiesis;
Hematopoietic Stem Cells;
cytology;
Humans;
Muscle, Skeletal;
cytology
- From:
Journal of Experimental Hematology
2015;23(5):1523-1526
- CountryChina
- Language:Chinese
-
Abstract:
Muscle-derived stem cells (MDSC) are defined as myogenic stem cells endowed with their ability to self-renew and differentiate into multiple cell types of their derivative tissue, and are proved to be over 10 times more efficient in hematopoiesis than hematopoietic stem cells (HSC). Although the mechanism which MDSC differentiate into blood cells is still unclear, MDSC were considered to replace HSC to treat the patients suffering from bone marrow diseases such as aplastic anemia and tumor. MDSC are different from HSC in a variety aspects like biological characteristics, protein expression and cell proliferation. On the other hand, MDSC contain multiple distinct stem cell populations. Among these, there is only a small part with the ability to repopulate hematopoietic cells, and it is still uncertain whether their origin is same as HSC. This review summarizes the difference between MDSC and HSC, the ability of MDSC to repopulate hematopoietic cells, and the prospect of MDSCs' transplantation.
