The effects of newly formed synthetic peptide on bone regeneration in rat calvarial defects.
10.5051/jpis.2010.40.1.11
- Author:
Jung Yoo CHOI
1
;
Ui Won JUNG
;
Chang Sung KIM
;
Tae Kwan EOM
;
Eun Jung KANG
;
Kyoo Sung CHO
;
Chong Kwan KIM
;
Seong Ho CHOI
Author Information
1. Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea. shchoi726@yuhs.ac
- Publication Type:Original Article
- Keywords:
Bone regeneration;
Collagen;
Synthetic peptide
- MeSH:
Animals;
Biocompatible Materials;
Bone Morphogenetic Proteins;
Bone Regeneration;
Collagen;
Extracellular Matrix;
Osteogenesis;
Rats;
Regeneration;
Skull
- From:Journal of Periodontal & Implant Science
2010;40(1):11-18
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Significant interest has emerged in the design of cell scaffolds that incorporate peptide sequences that correspond to known signaling domains in extracellular matrix and bone morphogenetic protein. The purpose of this study was to evaluate the bone regenerative effects of the synthetic peptide in a critical-size rat calvarial defect model. METHODS: Eight millimeter diameter standardized, circular, transosseus defects created on the cranium of forty rats were implanted with synthetic peptide, collagen, or both synthetic peptide and collagen. No material was was implanted the control group. The healing of each group was evaluated histologically and histomorphometrically after 2- and 8-week healing intervals. RESULTS: Surgical implantation of the synthetic peptide and collagen resulted in enhanced local bone formation at both 2 and 8 weeks compared to the control group. When the experimental groups were compared to each other, they showed a similar pattern of bone formation. The defect closure and new bone area were significantly different in synthetic peptide and collagen group at 8 weeks. CONCLUSIONS: Concerning the advantages of biomaterials, synthetic peptide can be an effective biomaterial for damaged periodontal regeneration.
