Research progress of miRNAs targeting GSK-3β in regulation of hepatocellular carcinoma invasion and metastasis.
- Author:
Song-Qi HE
1
;
Bin WEN
;
Guan-Xin CHEN
;
Hai-Tao SUN
;
Jia-Ling SUN
;
Xue-Mei YANG
Author Information
1. College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
- Publication Type:Journal Article
- From:
Journal of Southern Medical University
2017;37(1):138-140
- CountryChina
- Language:Chinese
-
Abstract:
Invasion and metastasis are key factors contributing to the high mortality rate of patients with hepatocellular carcinoma (HCC) involving a complex mechanism. In the invasion and metastasis of HCC, miRNAs can serve as either oncogenes or tumor suppressor genes to regulate the differentiation and proliferation of tumor cells being and play important roles in tumorigenesis, angiogenesis, invasion and metastasis. This review summarizes the recent progress in research of the molecular mechanisms by which miRNAs targeting GSK-3β regulate HCC invasion and metastasis and examines the roles of miRNAs in hepatocellular carcinoma cell proliferation, apoptosis, invasion, metastasis, and GSK-3β regulation.
