Sinogram restoration for low-dose cerebral perfusion CT images.
- Author:
Xiu-Mei TIAN
1
;
Jing HUANG
;
Jia-Hui LIN
;
Xin-Yu ZHANG
;
Jian-Hua MA
;
Zhao-Ying BIAN
Author Information
1. Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China. E-mail: 805988970@qq.com.
- Publication Type:Journal Article
- MeSH:
Algorithms;
Artifacts;
Cerebrum;
diagnostic imaging;
Humans;
Least-Squares Analysis;
Radiographic Image Interpretation, Computer-Assisted;
Tomography, X-Ray Computed
- From:
Journal of Southern Medical University
2016;37(4):470-474
- CountryChina
- Language:Chinese
-
Abstract:
In clinical cerebral perfusion CT examination, repeated scanning the region of interest in the cine mode increases the radiation dose of the patients, while decreasing the radiation dose by lowering the scanning current results in poor image quality and affects the clinical diagnosis. We propose a penalized weighted least-square (PWLS) method for recovering the projection data to improve the quality of low-dose cerebral perfusion CT imaged. This method incorporates the statistical distribution characteristics of brain perfusion CT projection data and uses the statistical properties of the projection data for modeling. The PWLS method was used to recover the data, and the Gauss-Seidel (GS) method was employed for iterative solving. Adaptive weighting is introduced between the original projection data and the projection data after PWLS restoration. The experimental results on the clinical data demonstrated that the PWLS-based sinogram restoration method improved noise reduction and artifact suppression as compared with the conventional noise reduction methods, and better retained the edges and details to generate better cerebral perfusion maps.
