Clinicopathological analysis of pulmonary vascular disease in 38 neonates died of respiratory failure.
- Author:
Ning LI
1
,
2
;
Hong-Wu CHEN
;
Xin-Hua ZHOU
;
Li LIANG
Author Information
1. 1Department of Neonatal Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
2. 3Department of Neonatal Medicine, Children's Hospital of Dongguan, Dongguan 523325, China. E-mail: 529822789@qq.com.
- Publication Type:Journal Article
- MeSH:
Death;
Humans;
Infant, Newborn;
Lung;
pathology;
Lung Diseases;
diagnosis;
Persistent Fetal Circulation Syndrome;
pathology;
Pulmonary Alveoli;
abnormalities;
pathology;
Respiratory Insufficiency;
mortality;
Vascular Diseases;
diagnosis;
Vascular Remodeling
- From:
Journal of Southern Medical University
2016;37(4):528-532
- CountryChina
- Language:Chinese
-
Abstract:
We reviewed the data of 38 neonates who died of respiratory failure. Paraffin sections of the autopsy lung samples were examined with HE staining or immunolabeling for CD34, CD68 and CK to observe the development of the pulmonary vessels and detect potential pulmonary vascular diseases (PVDs). Five cases were identified to have PVDs, including pulmonary hypertensive vascular remodeling in 3 cases and alveolar capillary dysplasia in 2 cases. The result indicated that PVD was one of the important reasons for respiratory failure in these neonates.
