Influence of apolipoprotein E gene polymorphism on the lipid regulation by xuezhikang capsule.
- Author:
Wei-Min JIANG
1
;
Ren-Sheng LAI
;
Xiao-Hu CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Apolipoproteins E; genetics; Cholesterol, HDL; blood; Drugs, Chinese Herbal; therapeutic use; Female; Genotype; Humans; Hyperlipidemias; blood; drug therapy; genetics; Lipid Metabolism; drug effects; Male; Middle Aged; Polymorphism, Genetic; Triglycerides; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2009;29(8):688-691
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the influence of apolipoprotein E (ApoE) gene polymorphism on the lipid metabolism regulatory effect of Xuezhikang Capsule (XZKC).
METHODSApoE polymorphism of 74 patients with hyperlipidemia was detected by gene sequencing method, and their plasma levels of total cholesterol (TC), triglyceride (TG), high- and low-density lipoprotein cholesterol (HDL-C and LDL-C) were determined before and after they received a 6-week treatment of XZKC, for analyzing the relationship between ApoE gene polymorphism and the changes of various blood lipids associated indices.
RESULTSThe effect of XZKC on reducing TG in the epsilon2 allele (E2/E2 and E2/E3 genotypes) was higher than that in the E3/E3 genotypes and epsilon4 allele (E3/E4 and E4/E4 genotypes), while on increasing HDL-C, it showed more effect in the epsilon4 allele (E3/E4 and E4/E4 genotypes) than that in the epsilon2 allele (E2/E2 and E2/E3 genotypes) and E3/E3 genotypes.
CONCLUSIONPatients' ApoE gene polymorphism could influence the lipid regulatory effect of XZKC, embodying mainly by raising HDL-C and reducing TG in patients with different ApoE genotypes to different extents.
