OBJECTIVETo establish a method to directly determine 21 elements in serum by dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS).

METHODSThe serum samples were diluted with 1% nitric acid by 3 times. The inductively coupled plasma mass spectrometry (ICP-MS) was used simultaneously to detect the serum concentrations of 21 elements (Be, Al, Mn, V, Cr, Fe, Co, Ni, Cu, Zn, As, Se, Mo, Ag, Cd, Sb, Ba, T1, Ph, Th, U).

RESULTSThe detection limits of all elements were between 0.001-0.0711 g/1. Standard linear correlation coefficients (r) were 50.999. Standard deviations were less than 5%,the recovery rates were 90%-114%. Standard reference materials were used for quality control standards and the analysis results conformed with the certified values.

CONCLUSIONThe present method is a simple, rapid,sensitive and accurate method for detecting the serum samples.