Study on the healing effect of pneumoconiosis with tetrandrine and massive whole-lung lavage.
- Author:
Li-Jun PENG
1
;
Qi-Shang ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Benzylisoquinolines; therapeutic use; Bronchoalveolar Lavage; Collagen Type III; blood; Combined Modality Therapy; Humans; Male; Middle Aged; Pneumoconiosis; blood; therapy; Transforming Growth Factor beta1; blood; Treatment Outcome
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2012;30(1):68-70
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the healing effect of pneumoconiosis with tetrandrine and massive whole-lung lavage.
METHODSChoose 34 confirmed pneumoconiosis patients as drug treatment group and complex treatment group, and 17 tested workers as control group. Collected the content of TGF-beta1 and P III P which in these three investigated groups.
RESULTSDrug treatment group and complex treatment group of patients improved the clinical symptoms and lung function Compared with Pretreatment, the FVC, FEV1.0, FEV1.0/FVC, MVV was obviously higher than those before treatment (P < 0.05). Complex treatment group than in the drug treatment group increased more significantly (P < 0.05). The level of TGF-beta1 and P III P was reduced after complex treatment (P < 0.05). Moreover,the level of TGF-beta1 and P III P in these patients are lower than in those patients treated with tetrandrine combined with whole lung lavage (P < 0.05).
CONCLUSIONTetrandrine combined with whole-lung lavage could significantly retard the development of pneumoconiosis by lessening the TGF-beta1 and P III P in serum.
