Correlation between HLA-DRB1*0901 and 1501, HLA-DQB1*0301 and 0602 alleles and esophageal squamous cell carcinoma of Kazakh in Xinjiang, China.
- Author:
Yun-zhao CHEN
1
;
Jian-ming HU
;
Chun-xia LIU
;
Lan YANG
;
Yan QI
;
Wen-ting LI
;
Liang YIN
;
Hong-an LI
;
Jin-fang JIANG
;
Wei-hua LIANG
;
Feng LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Alleles; Carcinoma, Squamous Cell; genetics; pathology; China; ethnology; Disease Susceptibility; Esophageal Neoplasms; genetics; pathology; Female; Gene Frequency; HLA-DQ Antigens; genetics; HLA-DQ beta-Chains; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Humans; Male; Membrane Glycoproteins; genetics; Middle Aged
- From: Chinese Journal of Pathology 2009;38(12):816-819
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the polymorphism of HLA-DRB1 and DQB1 allele in esophageal squamous cell carcinomas of Kazakh in Xinjiang, and to characterize susceptible genes for the family of Kazakh esophageal squamous cell carcinoma.
METHODSHLA-DRB1*0901, DRB1*1501, DQB1*0301, DQB1*0602 alleles were genotyped by sequence specific primers using polymerase chain reaction (PCR-SSP) in 200 Kazakh esophageal squamous cell carcinoma and 177 normal esophageal mucosa.
RESULTSThe frequency of HLA-DRB1*1501, HLA-DQB1*0301, HLA-DQB1*0602 alleles in 200 Kazakh esophageal squamous cell carcinoma (0.455, 0.760 and 0.690) were significantly higher than that of 177 normal esophageal mucosa (0.232, 0.520, 0.554; OR = 2.78, 2.93, 1.80; P < 0.05). The frequency of HLA-DRB1*0901 between the carcinoma (0.105) and control groups (0.102) had no association (OR = 1.036, P > 0.05); The frequency of HLA-DQB1*0602 was higher in poor-differentiated squamous cell carcinomas (0.742) than that of well-differentiated tumors (0.597, P < 0.05).
CONCLUSIONSHLA-DRB1*1501, HLA-DQB1*0301, HLA-DQB1* 0602 may be susceptible to Kazakh esophageal squamous cell carcinoma. HLA-DQB1*0602 correlates with well-differentiated esophageal squamous cell carcinoma.
