Expression and clinical significance of kidney injury molecule-1 in renal epithelial neoplasms.
- Author:
Ying-chun DONG
1
;
Bo WU
;
Jian-dong WANG
;
Qiu RAO
;
Heng-hui MA
;
Ru-song ZHANG
;
Hang-bo ZHOU
;
Zhen-feng LU
;
Xiao-jun ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adenoma, Oxyphilic; metabolism; pathology; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; genetics; metabolism; Bone Neoplasms; metabolism; secondary; Cadherins; metabolism; Carcinoma, Papillary; metabolism; pathology; Carcinoma, Renal Cell; genetics; metabolism; pathology; Chromosomes, Human, X; Gene Fusion; Hepatitis A Virus Cellular Receptor 1; Humans; Kidney Neoplasms; genetics; metabolism; pathology; Lung Neoplasms; metabolism; secondary; Membrane Glycoproteins; metabolism; Neoplasms, Glandular and Epithelial; classification; genetics; metabolism; pathology; Receptors, Virus; metabolism; Retrospective Studies; Translocation, Genetic
- From: Chinese Journal of Pathology 2010;39(1):35-39
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression and clinical significance of kidney injury molecule-1 (KIM-1) in primary and metastatic renal epithelial neoplasms.
METHODSA total of 136 cases of kidney neoplasms were retrospectively reviewed including 63 primary clear cell renal cell carcinomas (RCCs), 22 papillary RCCs, 13 chromophobe RCCs, 7 oncocytomas, 7 RCCs associated with Xp11.2 translocation/TFE3 gene fusions and 24 metastatic clear cell RCCs. Immunostaining for KIM-1 and kidney-specific-protein (Ksp)-cadherin were performed and the relationship to tumor stage and grade in clear cell RCCs was investigated.
RESULTSExpression of KIM-1 was detected in 77.8% (49/63) of clear cell RCCs, 90.9% (20/22) of papillary RCCs, 1/13 of chromophobe RCCs, 7/7 of RCCs associated with Xp11.2 translocation/TFE3 gene fusions and 87.5%(21/24) of the metastatic RCCs, but not detected in 7 cases of oncocytomas. A diffuse expression of KIM-1 was more frequently observed in Furhman nuclear grade III/IV clear cell RCCs (P = 0.010). Ksp-cadherin expression was mainly observed in chromophobe RCCs and oncocytomas.
CONCLUSIONSKIM-1 is a specific biomarker for injuried kidney proximal tubules and the corresponding neoplasms, and has a high specificity and sensitivity for primary or metastatic clear cell RCCs, papillary RCCs and RCCs associated with Xp11.2 translocation/TFE3 gene fusions. Combination of KIM-1 and Ksp-cadherin immunostaining can lead to a more precise histological classification of primary kidney epithelial neoplasms and improve the diagnostic accuracy of metastatic RCCs.
