Expression and diagnostic significance of CD34 in brain tumors of patients with refractory epilepsy.
- Author:
Jing LIU
1
;
De-hong LU
;
Yue-shan PIAO
;
Wei WANG
;
Li CHEN
;
Li-feng WEI
;
Hong YANG
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, CD34; metabolism; Astrocytoma; complications; metabolism; pathology; surgery; Brain Neoplasms; complications; metabolism; pathology; surgery; Diagnosis, Differential; Epilepsy; etiology; Ganglioglioma; complications; metabolism; pathology; surgery; Glioblastoma; complications; metabolism; pathology; Humans; Neoplasms, Neuroepithelial; complications; metabolism; pathology; surgery
- From: Chinese Journal of Pathology 2010;39(3):151-155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the immunohistochemical expression and diagnostic significance of CD34 in brain tumors of patients with refractory epilepsy.
METHODSImmunohistochemical study for CD34 was performed on formalin-fixed paraffin-embedded tissue blocks of 54 cases of brain tumors occurring in patients with refractory epilepsy. The tumor types included ganglioglioma (GG, number = 21), dysembryoplastic neuroepithelial tumor (DNT, number = 8), tumors/lesions which had the transitional features that between glioneuronal hamartia and mixed neuronal-glial tumor (number = 21) and pleomorphic xanthoastrocytoma (PXA, number = 4). Cases of glioblastoma (number = 4) and oligoastrocytoma (number = 5) were used as controls.
RESULTSTwenty of the 21 cases of GG, 1 of the 8 cases of DNT, 16 of the 21 cases of tumors/lesions which had the transitional features and 3 of the 4 cases of PXA showed cytoplasmic and membranous positivity for CD34. The adjoining brain tissues in 9 of the 18 cases of GG, 6 of the 16 cases of tumors/lesions which had the transitional features and 1 of the 3 cases of PXA also expressed CD34. In contrast, only 1 case of glioblastoma showed membranous positivity for CD34.
CONCLUSIONSCD34 preferred to staining for GG and PXA. Which represent a valuable tool for distinguishing GG, PXA and DNT, oligoastrocytoma, glioblastoma.
