In vitro study of oral Candida albicans in virulence from HIV-positive individuals.
- Author:
Xiao-song LIU
1
;
Hong-wei LIU
;
Zi-jie GUO
;
Wen-min LUAN
Author Information
- Publication Type:Journal Article
- MeSH: Acquired Immunodeficiency Syndrome; microbiology; Candida albicans; pathogenicity; Candidiasis, Oral; microbiology; HIV Seropositivity; microbiology; Humans
- From: Chinese Journal of Stomatology 2005;40(3):211-214
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the influence of Candida albicans on human immunodeficiency virus (HIV)-positive individuals susceptible to oral candidiasis.
METHODSIn vitro secreted aspartyl proteinase activities, adhesion to healthy buccal epithelial cells of Candida albicans isolates from oral cavities of subjects with and without HIV infection were measured.
RESULTSThe pathogenetic isolates of Candida albicans from HIV-positive patients were significantly lower than that from HIV-negative subjects (P < 0.01) in secreted aspartyl proteinase activities and adhesion to buccal epithelial cells. There was no difference in commensals between these two groups. In the HIV-positive group, no difference was found between the pathogenetics and the commensals. However, in the HIV-negative group, the virulence of the pathogen was significantly higher than the commensals (P < 0.01).
CONCLUSIONSThese results indicate that oral candidiasis was not correlated with some predominant strains of Candida albicans with higher virulence in HIV-positive subjects.
