The biochemical changes of hippocampus in patients before and after denture restoration: a preliminary 1H-magnetic resonance spectroscopy study.

Author: Qing-song JIANG ¹ ; Ting JIANG ; Zhen JIN ; Hai-lan FENG ; Ya-wei ZENG ; Jian LI
Author Information

1. Department of Stomatology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China.
Publication Type:Journal Article
MeSH: Aged; Aged, 80 and over; Denture, Partial, Removable; Female; Hippocampus; metabolism; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Tooth Loss; metabolism; therapy
From: Chinese Journal of Stomatology 2005;40(3):223-226
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the effects of reconstruction of lost occlusal support on the biochemical changes of nervous system.
METHODSThe changes of central nervous system metabolic compounds within hippocampus body were measured with proton magnetic resonance spectroscopy ((1)HMRS) before and after denture restoration (six weeks) in seven patients with prolonged loss of occlusal support.
RESULTS(1)HMRS indicated that Cho/Cr decreased by 11.9% (P < 0.05) six weeks after denture restoration, MI/Cr decreased by 28.8% (P < 0.05), and NAA/CR increased by 4.8% (P > 0.05) within hippocampus body.
CONCLUSIONSRecovery of occlusal support facilitates improvement of neuron functions in patients' hippocampus, which may help improve the functions of nervous system.