Expression of receptor activator of NF-kappa B ligand and osteoprotegerin protein in the giant cell lesions of jaw.
- Author:
Xue-mei MENG
1
;
Shi-feng YU
;
Ming-jie WEI
Author Information
- Publication Type:Journal Article
- MeSH: Giant Cells; metabolism; pathology; Humans; Jaw Diseases; metabolism; pathology; Osteoclasts; metabolism; Osteoprotegerin; metabolism; RANK Ligand; metabolism
- From: Chinese Journal of Stomatology 2005;40(4):294-297
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression of RANKL and OPG protein in the giant cell lesions of jaw and to study the mechanism of this lesion.
METHODSRANKL and OPG were detected by immunohistochemistry (SP) in 24 paraffin-embedded and 2 frozen specimens of central giant cell lesion of jaw.
RESULTSRANKL signals were strongly positive in the vascular epithelial cells. They also could be found in fibrous stroma, bone matrix, and stromal spindle cells, even in some cytomembrane of multinucleated giant cells. OPG was detected in multinucleated giant cells and a fraction of round mononuclear cells.
CONCLUSIONSActive vascular epithelial cells are contributed to the formation of multinucleated giant cells through regulating RANKL, and RANKL could play its role by paracrine and autocrine, which might be inhibited by OPG.
