The transformation of fibroblast-like cells originating from different tissue into osteoblasts.
- Author:
Quan-feng LUO
1
;
Xing WANG
;
Biao YI
;
Zi-li LI
;
Xiao-xia WANG
;
Cheng LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Morphogenetic Protein 2; pharmacology; Cells, Cultured; Fibroblasts; cytology; drug effects; Osteoblasts; cytology; drug effects; Osteogenesis, Distraction; Rabbits; Transforming Growth Factor beta1; pharmacology
- From: Chinese Journal of Stomatology 2005;40(4):327-330
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo discuss whether fibroblast-like cells can transform into osteoblasts under specific condition during distraction osteogenesis.
METHODSFibroblast-like cells were cultured in vitro. BMP-2, TGF-beta(1), BMP-2 and TGF-beta(1) were added into the medium, and the cellular change were observed by histochemistry and immunohistochemistry methods. The distraction was given on the membrane of fibroblast-like cells, and the cellular change were observed under the distraction.
RESULTSfibroblast-like cells from the joint could transform into osteoblasts under the effect of BMP-2 or BMP-2 with TGF-beta(1). Fibroblast-like cells from other regions could not transform into osteoblasts.
CONCLUSIONThe osteoblasts during distraction osteogenesis are multi-origin.
