The preliminary study on the characteristics of mandible and condyle in dentin matrix protein-1 gene knockout mice.
- Author:
Zu-bing LI
1
;
Zhi LI
;
Zheng-jun SHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Demineralization, Pathologic; genetics; pathology; Chondrogenesis; genetics; Extracellular Matrix Proteins; genetics; Gene Knockout Techniques; Mandible; pathology; Mandibular Condyle; pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteogenesis; genetics
- From: Chinese Journal of Stomatology 2005;40(4):335-337
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the characteristics of mandible and condyle in Dmp1 gene knockout mice, and to investigate the role of Dmp1 in the osteogenesis and mineralization of bone and cartilage.
METHODSDmp1-/-mice were executed at birth, 2 weeks, 2 months, 3 months and 5 months, and the mandible was taken out for physical, radiography, transmission electron microscopic, and histological examination. The difference between Dmp1 knockout mouse (ko) and wild type mouse (wt) in bone development, bone densitometry and histology were compared.
RESULTSThere were obvious changes in the mandible and condyle of Dmp1-/-mouse, such as incomplete ossification, low density, decreased volume and condyle cartilage degeneration.
CONCLUSIONSDmp1 is the key factor in the formation of growth plates and secondary ossification center, and plays an important role in the process of bone and cartilage formation and bone nodule remodeling. Dmp1 may be the candidate gene that controls the development of mandible and cartilage.
