Changes in antibody level after hepatitis B vaccination
- Author:
Nga Ngoc Cao
- Publication Type:Journal Article
- Keywords:
hepatitis B
- MeSH:
Hepatitis B;
Vaccination
- From:Journal of Practical Medicine
2002;407(1):7-10
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The study was conducted from 12/2000 to 12/ 2001 on 1997 medical students at Hå ChÝ Minh City Medico-Pharmaceutical University. 117 students who were negative with HBsAg, anti-HBs and anti-HBc were vaccinated with Merck Sharp & Dohm-produced vaccine. Three consecutive doses of 10mcg vaccine were delivered at 0, 1 and 6 months. Anti-HBs antibody was measured at 7 and 8 months of the study. It was noted that the second antibody titer was the third of first one. In the first assessment all participants had the antibody at protective level (i.e. 10mUI/ml or more), with mean titer was 789±304mUI/ml. 98.1% (105/107) of cases had anti-HBs level of 100mUI/ml or more, and 62.6% (67/107) of cases had reached the level of 1000mUI/ml or more. By 18 months, the mean antibody titer level was 248±209mUI/ml. The frequency distribution of anti-HBs level of 0mUI/ml, £10mUI/ml, 10 to £100mUI/ml, 100 to £1000mUI/ml and ³ 1000mUI/ml was 0 (0%), 1(0.9%), 5(4.7%), 35(32.7%), 59(55.1%) and 7(6.5%), respectively. The difference between two titer measures was statistical significant with p<0.001. However, there was no difference titers of male students (p=0.69) and female students (p=0.24). After 18 months of vaccination, there was only one acquired HBV case with anti-HBc (+) but had no clinical manifestation. No carrier was detected.
