Step Fisher discriminant analysis on severe clinical features of hand foot and mouth disease between enterovirus (EV)71 and other EV
10.3760/cma.j.issn.0254-6450.2011.07.018
- VernacularTitle:手足口病重症病例临床特征的Fisher逐步判别分析
- Author:
Feng RUAN
1
;
Ai-Jun TAN
;
Xue-Bao ZHANG
;
Xue-Qin CHEN
;
Song-Jian XIAO
;
Zhong-Wen YE
;
Song WANG
Author Information
1. 广东省珠海市疾病预防控制中心
- Keywords:
Hand foot and mouth disease;
Severe EV71;
Clinical feature;
Discriminant analysis
- From:
Chinese Journal of Epidemiology
2011;32(7):716-719
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical features of severe hand foot and mouth disease between enterovirus(EV)71 and other EV to find specific diagnosis index of EV71 severe hand foot and mouth disease.Methods Case definition were adopted from national guideline of hand foot and mouth disease diagnose(Version 2010).Clinical data of severe hand foot and mouth disease came from case history and contents of questionnaire would include the ones between the time of onset and diagnoses being made.EV and EV71,Cox A16 nucleic acid tested were by RT-PCR in stopl samples.Clinical features of severe hand foot and mouth disease between EV71 and other EV were compare.Results There appeared statistical differences between neurologic symptoms such as tremor,myoclonic jerk,listlessness,convulsion and white blood cell counts in CSF(P<0.05).Results from the step Fisher discriminant analysis showed only tremor and white blood cell had an increase in CSF,with statistically significant differences.The discriminant equation of EV71 was Y=3.059X1+3.83X5-2.742 and the equation of other EV was Y=1.634X1+1.623X5-1.693.The specificity of EV71 was 91% and the specificity of other EV Was 40%.Conclusion The increase of clinical features of tremor and white blood cell in CSF could be used as diagnosis index of severe EV71.
