Association between serum nitric oxide and hypertension among 1453 women in Suzhou
10.3760/cma.j.issn.0254-6450.2011.08.005
- VernacularTitle:苏州市1453名女性血清一氧化氮与高血压关系的研究
- Author:
Shi-Hui ZHANG
1
;
Jian-Song DING
;
Yang JIAO
;
Qiu ZHANG
;
Hao PENG
;
Xin GAO
;
Yan-Ying XU
;
Yong-Hong ZHANG
Author Information
1. 苏州大学医学部
- Keywords:
Hypertension;
Nitric oxide
- From:
Chinese Journal of Epidemiology
2011;32(8):760-763
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between serum nitric oxide (NO) and hypertension among women in Suzhou. Methods Blood pressure, height, weight and waist circumference (WC) were measured and factors including smoking, alcohol intake, family history of hypertension were investigated and blood glucose, blood lipid, serum NO were tested among 1453 women aged ≥30 years who lived in Jinchang district of Suzhou. Association between serum NO and hypertension was analyzed by univariate and multivariate methods. Results The mean levels of serum NO in hypertensive and normotensive persons were 28.17 (17.42-45.30)μmol/L and 27.56(17.19-44.42) μ mol/L, respectively, with no significant difference between the two groups (P ＞ 0.05).Results from multivariable logistic regression analysis showed that low serum NO was not associated with hypertension, after adjustment for confounders (OR=0.979, 95% CI: 0.747-1.283).The mean levels of systolic blood pressure / diastolic blood pressure were 130.1/83.3,128.5/82.7,129.8/83.2 and 129.1/83.3 mm Hg for whose serum NO level were in the first, second, third and fourth quartile,respectively. The risk of hypertension did not change along with the elevated serum NO levels.Compared to the first quartile of serum NO, the risks of hypertension in the second, third and fourth quartile did not change after adjustment for confounders and OR were 0.988 (0.709-1.377), 1.001(0.720-1.390) and 1.077 (0.774-1.499), respectively. Conclusion The serum NO level was not associated with hypertension in women in Suzhou.
