Effects of regulatory peptides on adhesion of eosinophil to bronchial epithelial cells.
- Author:
Yong TAN
1
;
Xiao-Qun QIN
;
Cha-Xiang GUAN
;
Chang-Qing ZHANG
Author Information
1. Department of Physiology, Xiang Ya Medical College, Central South University, Changsha 410078, Qinxq@public.cs.hn.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Antibodies;
pharmacology;
Bronchi;
cytology;
Cell Adhesion;
drug effects;
physiology;
Cells, Cultured;
Endothelin-1;
pharmacology;
Eosinophils;
physiology;
Epidermal Growth Factor;
pharmacology;
Epithelial Cells;
physiology;
Female;
Intercellular Adhesion Molecule-1;
immunology;
physiology;
Male;
Rabbits;
Vasoactive Intestinal Peptide;
pharmacology
- From:
Acta Physiologica Sinica
2002;54(1):43-46
- CountryChina
- Language:Chinese
-
Abstract:
To explore the roles of regulatory peptides in the process of various anaphylactic inflammation of the airway, we observed the influence of four peptides, i.e., vasoactive intestinal peptide (VIP), epidermal growth factor (EGF), endothelin-1 (ET-1), and calcitonin gene-related peptide (CGRP), on the adhesion of eosinophil (EOS) to unstimulated and O(3)-stressed bronchial epithelial cells (BEC). From the experiments we observed that VIP and EGF decreased EOS adherence to O(3)-stressed BEC and downregulated airway inflammation; ET-1 and CGRP increased the adhesion of EOS to BEC in the inflammatory process; and CGRP aggravated O(3)-stressed reactions. The effects of ET-1 and CGRP were inhibited by W(7)and H(7). Anti-ICAM-1 antibody inhibited the adhesion of EOS to BEC, which brings to light that EOS adherence to BEC may be related to the expression of ICAM-1 of BEC.
