Propofol depresses c -fos expression of NOS neurons in the spinal cord of rats with inflammatory pain.
- Author:
Ming YAN
1
,
2
,
3
;
Li-Cai ZHANG
;
Ti-Jun DAI
;
Yin-Ming ZHENG
;
Shi-Ming DUAN
Author Information
1. Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006
2. yjy3001@263.net
3. yjy3001@263.net
- Publication Type:Journal Article
- MeSH:
Animals;
Female;
Formaldehyde;
Male;
Neurons;
metabolism;
Nitric Oxide Synthase;
metabolism;
Pain;
chemically induced;
metabolism;
Propofol;
pharmacology;
Proto-Oncogene Proteins c-fos;
biosynthesis;
Rats;
Rats, Sprague-Dawley;
Spinal Cord;
metabolism
- From:
Acta Physiologica Sinica
2002;54(1):60-64
- CountryChina
- Language:Chinese
-
Abstract:
In formalin pain model, the effect of propofol on Fos expression in the spinal cord was examined by means of c -fos oncogene immunohistochemistry and NADPH-d histochemistry. Fos-like immunoreactive (FLI) neurons were mainly found in the ipsilateral dorsal horn after injection of formalin, some of which were FLI/NOS double-labeled neurons. Most of the FLI or FLI/NOS double-labeled neurons were observed in the medial part of lamina and the outer lamina . Before or after injection of formain, i.p. injection of propofol significantly decreased the number of FLI and FLI/NOS double-labeled neurons in all laminae (P<0.05 or P<0.01). By single i.p. injection of propofol or normal saline, few FLI neurons were found in the spinal cord. The results suggest that the antinociceptive function of propofol is possibly involved in the depression of the NOS neurons in the spinal cord.
