Bilateral regulatory action of corticotropin-releasing hormone on immune-mediated inflammation.
- Author:
Ce YANG
1
;
Jian-xin JIANG
Author Information
1. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Corticotropin-Releasing Hormone;
analysis;
chemistry;
genetics;
physiology;
Humans;
Inflammation;
etiology;
immunology
- From:
Chinese Journal of Traumatology
2009;12(6):350-354
- CountryChina
- Language:English
-
Abstract:
In trauma, infection and hemorrhagic shock derived stress, primary and secondary injury may result in severe derangement in the internal environment. The abnormal changes of immune-mediated inflammation interfere its pathogenesis and development directly. In recent years, various aspects of neuroendocrine responses, especially the regulatory effects of hypothalamic-pituitary-adrenal and sympathetico-adrenomedullary axes in inflammatory diseases have been the focus of research. Most importantly, corticotropin-releasing hormone (CRH) acts as a key player in the regulation of interactions between neuroendocrine and immunity both directly and indirectly. The paper summarized the recent development of CRH in the immune-mediated inflammation.
