Preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes.
- Author:
Sheng-jun MAO
1
;
Shi-xiang HOU
;
Hui JIN
;
Liang-ke ZHANG
;
Jiang-Bin
Author Information
- Publication Type:Journal Article
- MeSH: Drug Carriers; Drug Delivery Systems; methods; Glycyrrhetinic Acid; administration & dosage; Hepatocytes; Liposomes; Particle Size; Phospholipids; Succinic Anhydrides
- From: China Journal of Chinese Materia Medica 2003;28(4):328-331
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes.
METHOD3-succinic-30-stearyl glycyrrhetinic acid(Suc-GAOSt), one of the amphiphilic glycyrrhetinic acid derivatives, was synthesized as targeting molecules, liposomes surface-modified with glycyrrhetinic acid has been produced with ethanol injection method.
RESULTTargeting molecules can be mixed into the liposomal membrane. It was confirmed that the targeting molecules is 9% of the total lipids at the most in the liposomes.
CONCLUSIONLiposomes surface-modified with glycyrrhetinic acid was successfully prepared, which is considered to be a potential approach targeting to hepatocytes.
