Effects of Rbl on action potentials and force of contraction in guinea pig ventricular papillary muscles.
- Author:
Bin ZHANG
1
;
Shi-ao JIN
;
Xian KUANG
;
Wei-xing YAO
;
Guo-jing XIA
;
Ming-xing JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Action Potentials; drug effects; Animals; Calcium Channel Blockers; pharmacology; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Ginsenosides; isolation & purification; pharmacology; Guinea Pigs; Male; Myocardial Contraction; drug effects; Panax; chemistry; Papillary Muscles; physiology
- From: China Journal of Chinese Materia Medica 2003;28(4):366-368
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects of Rbl on action potentials and force of contraction in guinea pig ventricular papillary muscles.
METHODThe ventricular papillary muscles of guinea pig were isolated regularly and immersed with Tyrode, s solution. The effects of Rbl (purified saponins of panaxnotoginseng) on the action potentials (AP), the slow action potentials and the force of contraction (FC) of the muscles were studied. The AP and FC were measured synchronously.
RESULTRbl shortened the duration of AP, including APD2O and APD90, and reduced the FC(n = 5, P < 0.01), but didn't affect the rest potential (RP), the amplitude of action potential (APA), overshot (OS) and maximal upstrok velocity (Vmax). Rbl also decreased the APA of slow action potential, but quinidine had no such effects.
CONCLUSIONRbl may be a channel blocker.
