Experimental study on anti-pyretic effect of gegen qin lian decoction and its compounds.
- Author:
Lin-Zhong YU
1
;
Jie-yong WU
;
Jia-Bo LUO
;
Xu-Guang HUANG
;
Hong-xia SHAO
;
Hui LIN
Author Information
- Publication Type:Journal Article
- MeSH: Analgesics, Non-Narcotic; pharmacology; Animals; Coptis; chemistry; Drug Combinations; Drug Synergism; Drugs, Chinese Herbal; isolation & purification; pharmacology; Escherichia coli; Escherichia coli Infections; Fever; drug therapy; microbiology; Glycyrrhiza uralensis; chemistry; Male; Phytotherapy; Plant Roots; chemistry; Plants, Medicinal; chemistry; Pueraria; chemistry; Rats; Rats, Wistar; Scutellaria baicalensis; chemistry
- From: China Journal of Chinese Materia Medica 2004;29(7):663-666
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate composition principles of Gegen Qin Lian decoction through anti-pyretic experiment.
METHODPharmacological effects of different compounds of Gegen Qin Lian decoction according to six hours temperature response index (TRI6) and average top temperature response height (deltaT) after the decoction was given to feverish animal model by inactived bacteria suspension.
RESULTAs for reducing six hour temperature response index, Scutellaria baicalensis root was the main effective drug. Pueraria lobata root could enforce the effect while Coptis chinensis rhizome and Glycyrrhiza uralensis root counteracted it. As for reducing average top temperature response height, the Effects of four herbal drugs were the same as for TRI6.
CONCLUSIONOf the compounds of Gegen Qin Lian decoction, as to the pharmcological anti-pyretic effects, the best one is the compound of Scutellaria baicalensis and Pueraria lobata roots.
