Changes of amino acid content in hippocampus of epileptic rats treated with volatile oil of Acorus tatarinowii.
- Author:
Li CHEN
1
;
Wei-ping LIAO
Author Information
- Publication Type:Journal Article
- MeSH: Acorus; chemistry; Animals; Anticonvulsants; pharmacology; Aspartic Acid; metabolism; Epilepsy; chemically induced; metabolism; Glutamic Acid; metabolism; Hippocampus; metabolism; Kainic Acid; Male; Oils, Volatile; isolation & purification; pharmacology; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; gamma-Aminobutyric Acid; metabolism
- From: China Journal of Chinese Materia Medica 2004;29(7):670-673
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes of excitatory and inhibitory amino acid content in hippocampus of epileptic rats treated with volatile oil of A. tatarinowii, and explore the possible antiepiletic mechanism.
METHODThe volatile oil was extracted through Supercritical-CO2 Fluid Extraction (SFE-CO2), and epileptic models were built up by kainic acid (KA) lateral ventricle injection. The content of amino acid in hippocampus of epileptic rats treated with volatile oil was calculated.
RESULTThe content of GABA increased and Glu decreased prominently (P < 0.05) after volatile oil 35 mg x kg(-1) intraperitoneal injection.
CONCLUSIONThe volatile oil of A. tatarinowii can modulate the balance of excitatory and inhibitory amino acid in epileptic rats, thereby exerting its antiepileptic effect.
