Mechanisms of muscovite on gastric mucosal protective effect.
- Author:
Yun QIAN
1
;
Jian-Min SI
;
Liang-Jing WANG
;
Shu-Jie CHEN
;
You-Fa ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Aluminum Compounds; pharmacology; Animals; Dinoprostone; blood; Gastric Juice; chemistry; Gastric Mucosa; pathology; ultrastructure; Gastritis; blood; chemically induced; pathology; Hydrogen-Ion Concentration; Materia Medica; pharmacology; Microscopy, Electron, Scanning; Potassium Compounds; pharmacology; Protective Agents; pharmacology; Rats; Rats, Wistar; Silicates; pharmacology; Sodium Salicylate
- From: China Journal of Chinese Materia Medica 2004;29(8):781-785
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the mechanisms of muscovite gastric mucosal protective effect.
METHODRat model of chronic gastritis were used. After gastric mucosal injury was induced, the rats were divided into 6 groups and were treated with different drugs. 2 weeks later, the tissue and blood samples were obtained and measured.
RESULTThe general conditions, the observations under macroscopy, microscope and electron microscope of the middle and high dose of muscovite groups resembled those of the normal group. Their PH levels were higher than those of the model group, and the rates of intestinal metaplasia were lower, but the PGE2 level of the middle dose of muscovite group was the highest.
CONCLUSIONMuscovite can be adsorbed on the surface of the gastric mucosa. It has gastric mucosal protective effect by improving excretion of mucus and synthesis of PGE2 in gastric mucosa, restraining gastric acid, reversing of intestinal metaplasia and decreasing inflammation cells.
