Study rat nephrotoxicity of Longdan Xiegan Tang.
- Author:
Qing FANG
1
;
Xiao-Ping ZHAN
;
Jian-Ling MO
;
Mei SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Basement Membrane; ultrastructure; Blood Urea Nitrogen; Creatinine; blood; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; toxicity; Gentiana; chemistry; Kidney; ultrastructure; Kidney Cortex; metabolism; Magnoliopsida; chemistry; Male; Malondialdehyde; metabolism; Plants, Medicinal; chemistry; Proteinuria; chemically induced; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; metabolism
- From: China Journal of Chinese Materia Medica 2004;29(8):785-788
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the nephrotoxocity of Longdan Xiegan Tang in rats, and to test its safety.
METHODSprague-Dauley rats were given Longdan Xiegan Tang 4.5 mL x (100 mg)(-1) Bid for thirty days, and the control group was given NS. MTP, BUN, Cr, MDA, MTP/Ucr and SOD were measured on 1st, 2nd, 3rd, 4th week. The kidney tissues were viewed with light microscopy and electron microscope.
RESULTMTP and MTP/Ucr were obviously higher than controls ( P < 0.01), and the other index had no difference (P > 0.05). No remarkable structural change could been seen with light microscopy, but with electron microscope we could find that the basal membranes were thickened and some of foot process were infused.
CONCLUSIONLongdan Xiegan Tang will result in injury of kidney function.
