Tumor multidrug-resistance and reversing actions of traditional Chinese medicine.
- Author:
Jun-dong FENG
1
;
Xiao-yu XU
Author Information
1. College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400050, China. fengjun-dong2001@sohu.com
- Publication Type:Journal Article
- MeSH:
ATP-Binding Cassette, Sub-Family B, Member 1;
metabolism;
Animals;
Apoptosis;
drug effects;
Cell Line, Tumor;
DNA Repair;
drug effects;
Drug Resistance, Multiple;
Drug Resistance, Neoplasm;
Drugs, Chinese Herbal;
pharmacology;
Gene Expression Regulation, Neoplastic;
drug effects;
Humans;
Multidrug Resistance-Associated Proteins;
metabolism
- From:
China Journal of Chinese Materia Medica
2004;29(9):828-830
- CountryChina
- Language:Chinese
-
Abstract:
Tumor multidrug-resistance (MDR) is a major factor in chemotherapeutic failure. In recent years, the development of anti-MDR has become an important focus in research. The mechanisms of MDR relate to P-glycoprotein, MRP1, apoptosis, the unusual DNA repair, the organic micro-environment, and so on. This review summarized the advances in MDR mechanism research. At the same time, it summarized the recent research of traditional Chinese medicine in reversing MDR. Furthermore, their mechanisms and major features of actions were also discussed.
