Advance in flavonoids biosynthetic pathway and synthetic biology.

Author: Li-Qiu ZOU ¹ ; Cai-Xia WANG ² ; Xue-Jun KUANG ¹ ; Ying LI ¹ ; Chao SUN ¹
Author Information

1. Institute of Medicinal Plant Development, China Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Publication Type:Journal Article
Keywords: biosynthetic pathway; flavonoids; synthetic biology
From: China Journal of Chinese Materia Medica 2016;41(22):4124-4128
CountryChina
Language:Chinese
Abstract: Flavonoids are the valuable components in medicinal plants, which possess a variety of pharmacological activities, including anti-tumor, antioxidant and anti-inflammatory activities. There is an unambiguous understanding about flavonoids biosynthetic pathway, that is,2S-flavanones including naringenin and pinocembrin are the skeleton of other flavonoids and they can transform to other flavonoids through branched metabolic pathway. Elucidation of the flavonoids biosynthetic pathway lays a solid foundation for their synthetic biology. A few flavonoids have been produced in Escherichia coli or yeast with synthetic biological technologies, such as naringenin, pinocembrin and fisetin. Synthetic biology will provide a new way to get valuable flavonoids and promote the research and development of flavonoid drugs and health products, making flavonoids play more important roles in human diet and health.