A new nor-sesquiterpene from Cassia occidentalis and its bioactivity.
- Author:
Rui-Xin QIN
1
;
Qian ZUO
1
;
Xiao-Han HUANG
1
;
Hang-Ying MA
2
;
Yan YANG
2
;
Huan-Huan XING
2
;
Ling ZHOU
2
;
Min ZHOU
2
;
Qiu-Fen HU
2
Author Information
- Publication Type:Journal Article
- Keywords: Cassia occidentalis; cytotoxic activity; nor-sesquiterpenes
- From: China Journal of Chinese Materia Medica 2016;41(23):4389-4392
- CountryChina
- Language:Chinese
- Abstract: The phytochemistry investigation on the Cassia occidentalis, a Dai Medicine, was carried out. The C. occidentalis was extracted with ethanol and then partitioned with EtOAc. The EtOAc soluble materials were subjected repeatedly to column chromatography on silica gel and preparative RP-HPLC, leading to isolation of a nor-sesquiterpene, 3-isopropyl-1,6-dimethoxy-5-methyl-naphthalen-7-ol (1), and a sesquiterpene, 2,7-dihydroxy-4-isopropyl-6-methyl-naphthalene-1-carbaldehyde (2). Their structures were determined by means of spectroscopic studies. Compound 1 is a new compound. Compound 2 is also isolated from C. occidentalis for the first time. In addition, the cytotoxicity of compound 1 for NB4, A549, SHSY5Y, PC3, and MCF7 cells line was assayed by using the MTT method, and it displayed potential cytotoxicity for the tested cancer cell-line with IC₅₀ valves of (1.8±0.2), (1.2±0.2), (0.9±0.1), (2.2±0.3), (2.6±0.3) μmol•L⁻¹, respectively.
