Relationship between MnSOD polymorphisms and susceptibility of chronic poisoning exposed to manganism occupationally.
- Author:
Shao-lei CAI
1
;
Ming-xia SUN
;
Yong-jian YAN
;
Xiao-guang SUN
;
Bin LIN
;
Ji-hua FU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Manganese Poisoning; genetics; Middle Aged; Occupational Diseases; genetics; Occupational Exposure; Polymorphism, Single Nucleotide; Superoxide Dismutase; genetics
- From:Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(3):206-208
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between polymorphisms of MnSOD and the susceptibility of chronic poisoning exposed to manganism occupationally.
METHODSIn a study of case-control, genotypes were determined by PCR-RFLP in 164 patients with chronic occupational mangamism poisoning and 328 controls with age- and sex-matched for MnSOD 9Ala-Val.
RESULTSThere was a significant difference in the frequency of MnSOD 9Ala-Val at V locus mutant allele between cases and controls (χ(2) = 15.225, P < 0.01, 95%CI = 1.43 ∼ 3.00). Individuals with the genotype VV had a 1.30 of risk increase of occupational chronic manganism poisoning compared with the the genotype AV or AA (OR = 2.30, 95%CI = 1.52 ∼ 3.49, P < 0.05).
CONCLUSIONThe MnSOD polymorphisms may be related with the susceptibility to chronic occupational manganism poisoning, the risk of chronic occupational manganism poisoning increases in carriers with genotype VV at MnSOD 9Ala-Val locus.
