Abnormal increase in CD8(low) T lymphocyte in patients with occupational chronic lead poisoning.
- Author:
Wei YU
1
;
Ying LUO
;
Jia-yu CHEN
;
Wei-wei LIU
;
Ling-zhen CHEN
;
Jin-min WU
;
Yu ZHAN
;
Bo LI
;
Yang-qiu LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; CD8-Positive T-Lymphocytes; Case-Control Studies; Female; Humans; Lead Poisoning; immunology; Lymphocyte Count; Male; Occupational Diseases; immunology; Young Adult
- From:Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(3):222-223
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the changes in CD8(low) T lymphocyte subsets in patients with occupational chronic lead poisoning.
METHODSFlow cytometric analysis was used to count the numbers of CD8+ cells. 23 patients with occupational chronic lead poisoning and 20 controls were examined.
RESULTSCompared with control group (8.21% ± 3.02%), the CD8(low) T lymphocyte (12.98% ± 5.62%) were significantly increased in patients with occupational chronic lead poisoning.
CONCLUSIONAlthough the ratio of CD+ T lymphocyte is normal, the CD8 level is significantly decreased. The increase of CD8(low) T lymphocyte may be an important phenomenon of immuno-injury induced by lead. CD8(low) T lymphocyte could be an new direction for research of lead immuno-toxicity.