Clinical study on simvastatin treatment of pulmonary hypertension in patients with coal worker's pneumoconiosis.
- Author:
Duan-hua LI
1
;
Chao-jie WANG
;
Shu-sheng ZHANG
;
Heng MAO
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Anthracosis; complications; drug therapy; Coal Mining; Humans; Hypertension, Pulmonary; drug therapy; etiology; Male; Middle Aged; Simvastatin; therapeutic use
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(3):230-231
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe simvastatin treatment of pulmonary hypertension in patients with coal workers pneumoconiosis (CWP).
METHODS96 CWP patients with pulmonary hypertension were randomly divided into treatment and control groups. The control group was treated with 2.5 mg warfarin, once a day for four months; the treatment group was treated with 20 mg simvastatin, taken in evening, for 4 months. 6 min walking distance (6MWD) test and inspection pulmonary artery pressure were measured by echocardiography before and after treatment.
RESULTSIn the treatment group, the 6MWD were (258 ± 26) m after treatment and (225 ± 19) m before treatment, respectively. Compared with control group, pulmonary artery pressure was (41 ± 9) mm Hg in the treatment group before treatment, (36 ± 3) mm Hg in the treatment group after treatment, and (39 ± 5) mm Hg in control group, respectively, the difference was statistically significant (P < 0.05).
CONCLUSIONSSimvastatin can improve pulmonary hypertension in coal workers pneumoconiosis, and shows a definite curative effect.
