The assessment of hemoperfusion for the treatment of acute methamidophos poisoning.
- Author:
Deng-Pan LAI
1
;
Jian-Feng WANG
;
Ju-Ping YAO
;
Yi-Fen WANG
;
Guo-Qin CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Cholinesterases; metabolism; Female; Hemoperfusion; methods; Humans; Insecticides; poisoning; Male; Middle Aged; Organothiophosphorus Compounds; poisoning; Treatment Outcome; Young Adult
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(6):440-442
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of hemoperfusion(HP) about the patients of methamidophos poisoning.
METHODSOn the basis of comprehensive treatment,15 cases of severe acute methamidophos poisoning patients were treated with HP, Blood samples were collected at 7 time points, before and 5, 15, 30, 45, 60mins following the beginning and the end of hemoperfusion. Blood samples were used for measuring the concentration of methamidophos and perfusion devices were used for measuring the volume of methamidophos adsorbed by the device after hemoperfusion.
RESULTS15 patients live in 12 cases, 3 cases of death. HP (former) blood Cholinesterase vigor were 662.60 + 632.05, HP (after) blood cholinesterase vigor were 2577.52 + 920.38 IU/L; The difference of blood Cholinesterase vigor between the before and after HP was statistically significant (P < 0.01). The patients' methamidophos concentration of blood when HP treated 45, 60, 120 min were respectively (851 + 672), (680 + 529), (587 + 520) microg /ml, there were significantly lower than that the patients' methamidophos concentration of blood who were before HP (1659 + 1105) microg/ml, a statistically significant difference (P < 0.01).
CONCLUSIONHP can be cut down obviously methamidophos poisoning patients serum concentrations of toxic, the experimental method directly prove the clinical application of carbon HP can really adsorption methamidophos.
