- Author:
Hai-Ju HE
1
;
Bao-An CHEN
2
Author Information
- Publication Type:Journal Article
- MeSH: Abnormal Karyotype; Asian Continental Ancestry Group; Humans; Janus Kinase 2; Mutation; Primary Myelofibrosis; Prognosis; Risk Factors
- From: Journal of Experimental Hematology 2015;23(6):1721-1728
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical and laboratorial features of primary myelofibrosis (PMF) patients treated in our hospital, to analyze the risk factors influancing survival, and to compare several prognostic scoring systems.
METHODSparameters about clinical and laboratorial features were taken from medical documents at diagnosis, univariate analysis was conducted by Kaplan-Meier method, the survival data were compared with Log-rank test, and a COX model was used for multivariate analyses.
RESULTSIn our center the anemia and JAK2V617F mutation were more common, while the abnormal karyotype was less common, the constitutional symptoms, splenomegaly, Hb level < 100 g/L and LDH are adverse factors for survival in univariate analysis. Constitutional symptoms and Plt count < 100 × 10(9)/L are adverse factors of survival according to multivariate analysis.
CONCLUSIONThe anemia is more frequent in Chinese patients. Constitutional symptoms and Plt count < 100 × 10(9)/L are independent risk factors for survival. LILLI, modified IPSS, modified DIPSS are suitable to our data.