Research Progress on role of Abnormal Tryptophan Metabolism in Immune Thrombocytopenia.
10.7534/j.issn.1009-2137.2015.06.051
- Author:
Zhao-Jian LI
1
;
Xiao-Qian LIU
1
;
Jun-Qing XU
1
;
Xiao-Xia CHU
2
Author Information
1. Department of Hematology, Yuhuangding Hospital of Yantai Affiliated to Qingdao University Medical College, Yantai 264000, Shandong Province, China.
2. Department of Hematology, Yuhuangding Hospital of Yantai Affiliated to Qingdao University Medical College, Yantai 264000, Shandong Province, China. E-mail: lucychu66@163.com.
- Publication Type:Journal Article
- MeSH:
Autoantibodies;
Blood Platelets;
Humans;
Indoleamine-Pyrrole 2,3,-Dioxygenase;
Thrombocytopenia;
Thrombopoiesis;
Tryptophan
- From:
Journal of Experimental Hematology
2015;23(6):1813-1816
- CountryChina
- Language:Chinese
-
Abstract:
Immune thrombocytopenia (ITP) is a common acquired autoimmune hematological disorders. Platelet autoantibodies lead to the decrease of platelet production and (or) increase of its destruction. The latest researches showed that the abnormal tryptophan metabolism mediated by indoleamine-2, 3-dioxygenase(IDO) is related with the pathogenesis of ITP. The patients with ITP show less expression of IDO, reduction of Treg cells and increase of autoreactive T cells and autoantibodies. CTLA-4-Ig can improve the expression of IDO in the patients with ITP, which also can inhibit the proliferation and activation of self-reactive T cells. Thus, clarifying the abnormal tryptophan metabolism mediated by IDO may provide a new idea for improving the understand of the pathogenesis and treatment of ITP. This review focuses on reasearch progress of the tryptophan metabolism mediated by IDO and ITP.
