Cytogenetic Abnormalities and Outcomes of 117 Patients with Multiple Myeloma Detected by FISH.
- Author:
Bing ZHAI
1
;
Dan-Dan ZOU
2
;
Jian-Jun YAN
3
;
Nan WANG
1
;
Li-Li WANG
1
;
Hong-Li ZHU
2
;
Wen-Rong HUANG
1
;
Li YU
4
Author Information
- Publication Type:Journal Article
- MeSH: Chromosome Aberrations; Chromosome Deletion; Cytogenetics; Humans; In Situ Hybridization, Fluorescence; Multiple Myeloma; diagnosis; genetics; Prognosis; Retrospective Studies; Translocation, Genetic
- From: Journal of Experimental Hematology 2016;24(1):127-130
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the cytogenetic abnormalities and prognostic outcomes of patients with multiple myeloma (MM) detected by fluorescence in situ hybridization (FISH).
METHODSThe clinical record of 117 newly-diagnosed patients with MM treated in department of hematology and geriatric hematology of our hospital for 7 years were collected, and their molecular cytogenetic abnormalities detected by FISH and the clinical outcome were analyzed retrospectively.
RESULTSThe detected rate of cytogenetic abnormality was 76.9%(90/117), the most common abnormality deteted by FISH was 1q21+ (71.1%), followed by 13q- (56.6%). The cross comparison method showed that 13q- and 17p13-, t(11;14) and t(4;14) were related respectively. All the patients with cytogenetic abnormalities showed no significant difference in the overall survival from cytogenetic normal patients.
CONCLUSIONThe positive rate of molecular cytogenetic abnormalities detected by FISH in MM patients is high, but data from larger and longer studies are needed to evaluate the prognostic outcomes.
