Effect of Dexamethasone on Blast Composition in Patients with Myelodysplastic Syndrome and Its Diagnostic Significance.
- Author:
Fan ZHANG
1
;
Zhao-Bo LI
1
;
Ning-Ning WANG
1
;
Shuai LIU
1
;
Bao-Hong YUE
2
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, CD34; metabolism; Dexamethasone; therapeutic use; Flow Cytometry; Granulocytes; cytology; Humans; Monocytes; cytology; Myelodysplastic Syndromes; drug therapy; Precursor Cells, B-Lymphoid; cytology; Proto-Oncogene Proteins c-kit; metabolism
- From: Journal of Experimental Hematology 2016;24(1):144-149
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the effect of dexamethason (Dex) on blast composition in patients with myelodysplastic syndrome (MDS) and investigate its significance in diagnosis of MDS.
METHODSThe flow cytometry (FCM) was used to detect the blast rate and the expression of its antigens in 30 cases of MDS (10 cases were treated with Dex as DX group and 20 cases were treated without Dex as control group).
RESULTSThe difference of the CD34(+) cell number detected by FCM was not statistically significant between DX group and control group (P > 0.05); The rate of BM B cell precursors (BCP CD34(+)/CD19(+)/CD10(+) cells) increased in DX group significantly, and BM CD117(+) cells in CD34(+) cells was decreased significantly as compared with control group (P < 0.001). The expression of antigens between granulocyte and monocyte was not significantly different (P > 0.05).
CONCLUSIONThe dexamethasone can increase the rate of BCP significantly and decreased the rate of BM CD117(+) cells in CD34(+) cells significantly. There is significant influence on the blast composition in MDS patients after dexamethasone treatment and without significant influence on the other phenotypcs.
