Role of SOX7 in Hematopoietic System Development and Hematological Malignancies--Review.
10.7534/j.issn.1009-2137.2016.01.044
- Author:
Wen-Ming WANG
1
;
Jing WANG
1
;
Hong-Mei JING
2
Author Information
1. Department of Hematology, Peking University Third Hospital, Beijing 100191, China.
2. Department of Hematology, Peking University Third Hospital, Beijing 100191, China. E-mail: jinghm@yahoo.com.
- Publication Type:Journal Article
- MeSH:
DNA Methylation;
Gene Silencing;
Hematologic Neoplasms;
genetics;
metabolism;
Hematopoietic System;
physiopathology;
Humans;
SOXF Transcription Factors;
genetics;
metabolism;
Wnt Signaling Pathway
- From:
Journal of Experimental Hematology
2016;24(1):233-236
- CountryChina
- Language:Chinese
-
Abstract:
The sex-determining region Y-box 7 (Sox7) is a important member of SOX family containing high mobi- lity group (HMG), mapped to human chromosome 8p23.1. Wnt/β-catenin signaling pathway plays an important role in cell survival, differentiation, self-renewal, proliferation and apoptosis, and is closely related with carcinogenesis. SOX7 gene is likely to be a tumor suppressor gene in MDS and other hematological malignancies. As a negative regulator of the WNT/β-catenin signaling pathway, the function loss of this gene can lead to carcinogenesis. The methylation of SOX7 gene leads to the silence of this gene, resulting in tumorigenesis. The decision of hematopoietic stem cells to self-renew or differentiate is a stochastic process, but SOX7 can promote the differentiation into all blood cell types. This review focuses on the role of SOX7 in hematopoietic system development and hematological malignancies.
